Avana 50mg (Avanafil)

Erectile dysfunction is a condition where a man cannot get or keep an erection suitable for a sexual activity. There are various causes to this condition, mainly due to the narrowing of arteries where blood flows to the penis.
Avana 50 contains 50mg of Avanafil as the active ingredient.  This drug works by preventing the action of phosphodiesterase-5 to help widen the blood vessel and improve blood flow to the penis. This action helps men get and keep an erection following sexual stimulation. A tablet of Avana will not produce an erection on its own.

Manufacturer

Avana is manufactured by Sunrise Remedies Pvt. Ltd

Dosage

The recommended starting dose of Avanafil is 50mg per day. A tablet must be taken orally, as needed, taken about 15 to 30 minutes before an anticipated sexual activity. Depending on a patient’s response and tolerance to the drug, the dose may be adjusted by a physician, either reduced  or increased to the maximum dose of 200mg a day taken 15 minutes before sexual activity. The prescribed dose must not exceed once a day.

While Avanafil belongs to the drug class called PDE5 inhibitors, it works much faster as compared to other belonging to the same class, such as Sildenafil, Vardenafil and Tadalafil. Avanafil works in about 15 to 30 minutes, as compared to the onset of 30 minutes to 60 minutes of other PDE5 inhibitors. This drug is not affected by high-fat meals, unlike Sildenafil and Vardenafil. A tablet of Avana 50 may be taken with or without food.

Patients taking medications that may affect blood levels of Avanafil must not exceed a dose of 50mg in 24 hours.

Contraindications

Avana 50 is contraindicated to patients allergic to the active ingredient Avanafil, and to any of the tablet’s inactive ingredient.
Men advised not to engage in sexual activity must also avoid the use of this drug. Other medical conditions in which this drug is contraindicated to include:

• Severe liver and kidney impairment
• Degenerative eye problems
• Certain heart problems like unstable angina, severe heart failure, angina during sexual intercourse
• Low or uncontrolled high blood pressure
• Heart attack or stroke in the past 6 months
  

Avana is also contraindicated to patients using nitrates in any form, recreational drugs, other PDE5 inhibitors, guanylate cyclase stimulators, and CYP3A4 inhibitors, for it may cause potentially fatal or serious side effects.

Side effects

Common side effects of Avana include (but not limited to):

• Headache
• Flushing
• Nasal congestion
• Back pain
• Constipation
• Nausea
• Dyspepsia

Medical attention is needed urgently if any of these rare side effects occur:

• Fast or irregular heartbeat
• Chest pain
• Fainting
• Severe dizziness
• Vision changes
• Ringing in the ears
• Sudden decrease or loss of vision
• Sudden decrease or loss of hearing

Avanafil has shown less inhibition of PDE enzymes found in the heart, retina and testicles as compared to Sildenafil, which could mean having a reduced incidence of side effects of visual disturbances, cardiovascular and musculoskeletal effects.
Avana 50 may cause painful and prolonged erection that may last for more than 4 hours. Urgent medical help is needed if this occurs to prevent further permanent damage to the penis.
Severe allergic reaction may rarely occur, but medication use must be stopped and emergency medical help is needed if it does occur. Symptoms include rash; hives; itching; difficult breathing; tightness in chest; swelling of mouth, lips, eyelids, tongue, face, throat

Warnings and Precautions

Patients with underlying heart conditions are at risk of cardiovascular effects during sexual activity like heart attack or stroke. Symptoms of heart attack may include chest, shoulder, neck or jaw pain; severe dizziness, headache, nausea, vomiting; fainting; numbness of an arm or leg; vision changes. Symptoms of stroke may include confusion, one-sided weakness, fainting, vision or speech changes.

Priapism may also occur in patients with predisposing conditions such as sickle cell anemia, leukemia, or multiple myeloma.

Caution must be observed in patients taking these medications that Avana may interact with:

• Alpha-blockers
• Azole antifungals
• Macrolide antibiotics
• Protease inhibitors
• Hydantoin anticonvulsants
• Barbiturates
• Seizure drugs
• Rifamycin

Caution is advised when driving and doing unsafe tasks while taking this drug as it may cause dizziness, fainting and visual disturbances.
Avana does not prevent pregnancy. Using birth controls will prevent a partner from getting pregnant. This drug does not protect against sexually transmitted diseases. Barrier form of birth control will prevent acquiring such diseases.
This drug is not intended for use by women and children.

Avana and Alcohol

Alcohol consumption is not recommended while taking Avana for it may increase the risk of dizziness, headache, orthostatic hypotension, and increased heart rate.

Avana and Grapefruit

Consuming grapefruit and grapefruit juice while taking Avana is not recommended for it may increase the level of Avana in the blood, increasing the risk of side effects.